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Laryngoscope 131: E1741E1747

Abstract Mitochondria are the primary intracellular site of oxygen consumption and the major source of reactive oxygen species (ROS), most of them originating from the mitochondrial respiratory chain

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Consequently, MSU crystals can shift local inflammation from a transient defense mechanism to ongoing tissue remodeling through the activation of inflammatory corpuscles and the programmed response of immune cells

doi: 10.1111/j.13652826.2005.01370.x 86 OsterstockGMitutsovaVBarreAGranierMFontanaudPChazalonMet al

My recommendation is to stay on the lower end of these recommendations for two reasons: #1