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MOTS-c half-life is approximately 2 to 4 hours, but the downstream cellular effects (mitochondrial biogenesis, gene expression changes) persist well beyond serum clearance

400 Another randomized controlled trial in 4,745 patients with a recent history of heart attack found adding 0.5 mg of colchicine daily to preventive therapy lowered the rate of major cardiovascular events by 23% relative to placebo during a median follow-up of 22.6 months

Rioux JA, Golvan YJ, Houin R

Glutathione-peroxidase-1 null muscle progenitor cells are globally defective

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