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In in vitro and in vivo studies, AC suppressed the vascular endothelial injury induced by complement noted by lowered adhesion molecules (ICAM-1, VCAM-1), and NF-B transcriptional activity, significantly reducing leukocyte infiltration, as well BALF protein content, and pulmonary MPO activity (Guo et al

Nitschke, W., McGlynn, S

And here's where it get difficult again...there are many types of anaemia (not just macrocytic or iron anaemia) so pinning the anaemia down to just those causes (especially if those potential causes are being treated) might be a reductive approach - especially as you still have symptoms which could be due to anaemia

Downregulation is a longer term process (over tens of minutes to hours) that is associated with: (1) receptor internalization into vesicles and its trafficking and destruction in the lysosomes