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A variety of inflammatory mediators and cell adhesion molecules are involved in the regulation of inflammation, and the interactions between them together constitute a complex regulatory network (Gao et al., 2019a)

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Gurbuz, I., Yesilada, E

Yang et al., An ROS-responsive artesunate prodrug nanosystem co-delivers dexamethasone for rheumatoid arthritis treatment through the HIF-1/NF-B cascade regulation of ROS scavenging and macrophage repolarization

In this cycle, GSH is released from the cell by carrier mediated transporter(s) and the ecto-enzyme GGT then transfers the -glutamyl moiety of GSH to an amino acid (the best acceptor being cystine), forming -glutamyl amino acid and cysteinylglycine