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It supports: Red blood cell production Nervous system function DNA synthesis Energy metabolism A deficiency in Vitamin B12 can lead to fatigue, weakness, nerve damage, and anaemia

Within cancer cells lactate is the primary substrate for TCA cycle activity as well

Functional validation (cognitive testing, synaptic marker assays) is often more practical than pharmacokinetic sampling for confirming protocol effectiveness

In these models, fibroblasts efficiently migrate, proliferate, and deposit matrix components to facilitate initial wound closure, yet they do not persistently differentiate into highly contractile, matrix-overproducing myofibroblasts