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In addition, investigations indicate that mitochondrial dysfunction in sepsis is a serious factor in organ failure

Although CPT1A and CPT1B exhibit considerable sequence similarity, the sensitivity of these two enzymes to their physiological inhibitor, malonyl-CoA, differs greatly (CPT1A has a ten-fold higher Ki for malonyl-CoA) 39,40

Hemodialysis patients commonly receive 10-20 mg/kg intravenously at the end of each dialysis session, with trough free carnitine concentrations guiding subsequent adjustments

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(PubMed) Clark WM, Williams BJ, Selzer KA, Zweifler RM, Sabounjian LA, Gammans RE

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