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Description
A significant correlation has been observed among diabetes duration, diabetes control, and vitamin B12 deficiency in some studies
Astroglial degeneration and death (Clasmatodendrosis) Many neuropathologies, including for example traumatic lesions, stroke or age-dependent diseases are associated with direct damage of astrocytes, causing their degeneration and death

Curcumin exerts potent antioxidant, anti-inflammatory, and anticancer effects by modulating multiple signaling pathways, including NF-B, PI3K/Akt, and Wnt/-catenin

Lancet 354, 16761681

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GSH production is supported by NRF2 through controlling several enzymes responsible for GSH synthesis, such as the glutamate-cysteine ligase (GCL) complex composed of two subunits, the modifier (GCLM) subunit and the catalytic (GCLC) subunit, which catalyze the rate-limiting step of GSH synthesis that converts cysteine and glutamate into GSH [22]
