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Interestingly, TMAO lowered expression levels of SIRT1 and increased oxidative stress, both in vivo and in vitro by triggering the p53/p21/retinoblastoma tumor suppressor signaling pathways [62]
Remington R, Chan A, Paskavitz J, Shea TB

22(1): 4654 Jiang X, Williams KM, Liauw WS, et al
According to this view, mtDNA showed more oxidative damage as indexed by levels of 8-OHdG isolated from mouse liver, heart, and brain than nDNA from the same tissues (50, 58)
Tyni T, Pihko H, Kivela T: Ophthalmic pathology in long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency caused by the G1528C mutation

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