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Epigenetics: You Are More Than Your Genes Epigeneticsthe study of how lifestyle choices affect gene expressionshows that diet, stress, and toxin exposure all impact how genes function [8]

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10.7150/jca.57054 173 ZhangW.NingN.HuangJ

Hypoxia induces the overexpression of Hilpda, which leads to triglyceride overload and FAO defects by downregulating adipose triglyceride lipase (ATGL), triggering mitochondrial dysfunction and upregulating profibrotic factors (TGF-1, -SMA, type I collagen) while reducing the expression of cyclin-dependent kinase 1 (CDK1) and increasing the CyclinB1/D1 ratio, collectively promoting renal tubular fibrosis [85]