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Heparanase is also overexpressed in some malignant tumors and is activated in sepsis, causing partial degradation of the glycocalyx, which further exacerbates the loss of glycocalyx components (65)

This article covers the biological mechanisms BPC-157 targets in reflux pathology, the preclinical evidence base for gastric mucosal protection, the absence of human clinical trials, and what researchers should understand about peptide purity and storage when designing GERD-related studies