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Paneth cells produce antimicrobial peptides or lectins, including REG3 proteins and defensins

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GPX3 is predominantly present in plasma (Zhao et al., 2019)

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Since the production of -glutamyl peptides is elevated under certain pathological conditions, it is conceivable that they transmit signals from damaged cells to surrounding cells via the modulation of CaSR action

PMID: 18936223