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The gut microbiota converts L-carnitine into trimethylamine (TMA), which may then be oxidized by enzymes in the liver to form trimethylamine N-oxide (TMAO)

K.VangA.et al (2023a)

Many people have hypo-clinical hypothyroidism, which makes it very difficult to realise and test for

various eye and vision abnormalities such as decreased blink rate, dry eyes, deficient ocular pursuit (eye tracking) and saccadic movements (fast automatic movements of both eyes in the same direction), difficulties in directing gaze upward, and blurred or double vision

doi: 10.12938/bmfh.17-010 48 LiW.ZhangK.YangH

As such, it may be expected that TRIM-mediated ubiquitination of autophagy substrates leading to their recognition by ubiquitin binding receptors such as the SLRs would be a common mechanism of TRIM-mediated selective autophagy