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in fact, Se depletion is implied in the pathogenesis of hepatic inflammation and fibrosis [91], which are NAFLD-related injuries

120 SuraceM

In CKD, systemic inflammation elevates pro-inflammatory cytokines such as IL-6 and TNF-, which upregulate RANKL expression while suppressing OPG, a decoy receptor that curbs RANKL activity, thereby tipping the balance toward osteoclastogenesis (43)

Cells 10 , 2483 (2021)

Being a powerful antioxidant, vitamin C is of vital importance when it comes to fighting inflammation

Considering that oxidative stress generally interacts with inflammation to form a complex pathological microenvironment, multifunctional nanomedicine may achieve a synergistic effect and obtain optimal therapeutic outcomes [203, 204]