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This was related to a decreased expression of Ki67 (a marker of cell proliferation) and a downregulation of cyclin A, cyclin D1, and CDK2, which regulate cell cycle progression (31)

100 dietary bioactive compounds, the compound producing the highest maximal response E max for GLO1-ARE transcriptional activity was trans -resveratrol (tRES) and the compound with the lowest median effective concentration, EC 50, was hesperetin (HESP)

[DOI] [PubMed] [Google Scholar] 262.Kravchenko L.V., Aksenov I.V., Nikitin N.S., Guseva G.V., Avrenyeva L.I., Trusov N.V., Balakina A.S., Tutelyan V.A

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Although such direct transcriptional modulation in human brain tissue has not yet been confirmed, related studies in human liver cells indicate that naringenin downregulates IRE1 expression, alleviates ER stress, and restores insulin responsiveness, pointing to its regulatory effects on insulin signaling at the gene expression level in human systems (Jia et al., 2019)

It just needs to be interpreted carefully