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10.1016/j.phymed.2024.155340 179 WuX.PanJ.YuJ

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27 Consistent with the lack of mitochondrial involvement, erastin did not cause ATP depletion, and morphologically, mitochondria appeared smaller and denser, but not swollen or ruptured as seen in classical necrotic cell death

The details of dietary uptake and cellular storage and utilization of iron are presented in the Iron and Copper Homeostasis page, thus, this discussion will be limited to the role of ascorbate in the overall processes

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It is primarily found in silymarin, which is a mixture of polyphenolic flavonoids extracted from the seeds and fruits of milk thistle and includes silybin A, silybin B, and isosilybin, among others ( Figure 1 ) ( Figure 2 shows the chemical structures of the main components in silymarin ( Figure 1 Figure 2 Inflammation is the pathological basis of various diseases, involving complex cellular signaling and immune regulation mechanisms