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Future perspectives Potential difficulties in many clinical trials investigating PIPN prevention include small sample sizes, the absence of placebo control groups, varying dosing and treatment regimens of investigational medications, non-standardized definitions and assessments of neuropathy, and inclusion of cancer patients receiving different chemotherapy treatment protocols

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[20] [21] [22] [23] Starting in 2007, health agencies in various countries began issuing warnings against their use

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The national cancer institute clinical trials planning meeting for prevention and treatment of chemotherapy-induced peripheral neuropathy

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