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Many nanozymes are capable of catalyzing multiple substrates, such as peroxidase-like nanozymes that oxidize various organic substrates in the presence of H 2 O 2 , while also facilitating the transformation of substrates through different reaction pathways, such as decomposing H 2 O 2 to produce OH (peroxidase-like activity) or O 2 (catalase-like activity) 35

These changes indicate a systemic dysregulation of amino acid metabolism and redox processes, which include the metabolism of glutathione, nicotinate, and nicotinamide

doi: 10.1002/glia.10346

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Effect of peroxynitrite on the mitochondrial respiratory chain: differential susceptibility of neurones and astrocytes in primary culture