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Key MechanismsRedox Balance, Detoxification, & Neuroprotection Glutathione (GSH) governs cellular redox homeostasis and detoxifies reactive oxygen and nitrogen species (RONS), protecting neurons that are particularly vulnerable due to high metabolic demand and oxygen use

It is interesting to speculate whether the ability of digoxin to inhibit both osteoclast differentiation and hypoxic bone resorption by mature osteoclasts is due to its ability to inhibit both isoforms of HIF

10.1016/j.lfs.2013.04.003 [DOI] [PubMed] [Google Scholar] Kaul S., Kapoor N

The mechanism of ferroptosis is complex and varied but it is essentially an imbalance between oxidation and antioxidant systems, resulting in cellular lipid peroxidation (62)