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The ultimate aim of any experimental system should be replication of human pathophysiology which is central to translate findings to the clinic

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Additionally, cofactors needed to optimize remethylation of homocysteine to form methionine are required to recycle the homocysteine to methionine for reuse as SAMe (Figure 54-10)

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Red wine polyphenols induce vasorelaxation by increased nitric oxide bioactivity

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