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doi: 10.1021/bi701599e

Interestingly in the rat study, an oxidation pathway forming M1 and onward oxidation to M5 dominated in males comprising 33.9% and 20.1% respectively of total radioactivity vs 17.9% of parent

It is imperative to note that cycloastragenol has been demonstrated to possess no inherent toxic or genotoxic potential

It's also essential for building and repairing tissues and creating proteins

Several works are underway to develop small molecule-based inhibitors of Keap1/Nrf2 using several approaches like target-based virtual screening, fragment-based drug design, high-throughput screening, structure-based optimization, etc (Zhuang et al., 2017

Short peptides such as CAQK are also amenable to other routes of administration, such as intranasal delivery