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The final decision must be the result of an individualized assessment, considering the size, location, risks derived from a surgical intervention, the risk-benefit ratio and the patient's life expectations

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Yet fewer than 5% of these reactions indicated actual adverse events requiring medical intervention

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Live/dead cell discrimination was done using the LIVE/DEAD Fixable Near-IR Dead Cell Stain Kit (L34975, Invitrogen,USA)

Anesthesiology 125:133146 Zhang X, Liu S, MG P, Newport GD, Callicott R, Berridge MS, Apana SM, Jr SW, C W (2013) Protective effects of acetyl l-carnitine on inhalation anesthetic-induced neuronal damage in the nonhuman primate