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Intestinal inflammation and consequent systemic inflammation Cytokines and chemokines are crucial for intercellular communication and contribute to maintain intestinal homeostasis through inflammatory mechanisms, but when these are constantly elevated, epithelial barrier integrity results compromised [119]

The composition of these microbial communities varies across different body sites and is influenced by various factors including host genetics, age, sex, weight, diet, immune system, oxygen levels, pH, bile acids, gastrointestinal transit time, mucus production, disease states, medications, probiotics, certain surgeries like gastric bypass, and environmental factors (9-15)

doi: 10.1038/mi.2014.53 83

Currently, the TME is regarded as a possible therapeutic target for ovarian cancer

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Parkinson's disease: from pathogenesis to pharmacogenomics