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Evolutionary Analysis and Classification of OATs, OCTs, OCTNs, and Other SLC22 Transporters: Structure-Function Implications and Analysis of Sequence Motifs

10.1016/j.bej.2016.10.021 Biochem

doi: 10.1007/978-3-031-21547-6_8

The general endogenous antioxidant system consisting of enzymatic antioxidants (SOD, CAT, GPx, and Trx) and nonenzymatic antioxidants (vitamins or its analogs, minerals, and metabolites) protects cell from oxidative damage

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From the discussion above, it is apparent that MitoSOX fluorescence results do not provide experimental proof for increased generation of mitochondrial superoxide in TIGAR-deleted cells, and that the enhanced MitoSOX fluorescence is likely due to enhanced oxidation of MitoSOX to Mito-E + by H 2 O 2 and iron or perferryl iron (Fig