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[DOI] [PMC free article] [PubMed] [Google Scholar] 65.Gong Y., Yang J., Cai J., Liu Q., Zhang Z

Hence, we showed that both liver models produce CCBL enzymes that have the ability to cleave the C-S bond of cysteine conjugates, which tends to demonstrate the involvement of the liver in the formation of these thiomethyl metabolites

Three repeats were made for each reaction condition in a 384 well plate

[DOI] [PubMed] [Google Scholar] Merryman C

In this category, cis -6-(2-acetylvinylthio)-purine (cAVTP) and trans -6-(2-acetylvinylthio)-guanine (tAVTG) contain active thiopurines (6-mercaptopurine and 6-thioguanine, respectively) liberated intracellularly after GSH-conjugation catalyzed by GST M1-1, M2-2, and A4-4, but not GST P1-1 (Gunnarsdottir et al., 2002

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