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Hepatology 31 , 907915 (2000)

There are a number of key compounds that have been identified to support each of these specific pathways, including sulfation, methylation, glutathione conjugation, acetylation, glucoronidation and glycine (amino acid) conjugation

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Another was the discovery that tight junctional permeability is dynamic, altered by systemic inflammation and other factors such as enterotoxins and the volume of fluid absorption [23, 39], initially reported in the early 1980s in clinical studies of intestinal permeability in arthritis and celiac disease patients [37, 40]