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But compelling preclinical data does not translate reliably to human outcomes

Biomed Pharmacother 89:11961206 El Morsy E, Ahmed M (2020) Protective effects of lycopene on hippocampal neurotoxicity and memory impairment induced by bisphenol A in rats

doi: 10.1172/JCI116109

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More importantly, the downregulation of the EZH2 gene leads to a decrease in LAT1 ( SLC7A5 ) expression, and, in turn, the downregulation of LAT1 ( SLC7A5 ) or the depletion of essential amino acids can also induce a decrease in EZH2 expression (Dann et al., SLC7A5 ) indicates the potential of LAT1 ( SLC7A5 ) as a target for cancer therapy (Hafliger and Charles, 2019)

Intrauterine growth retardation and consequences for endocrine and cardiovascular diseases in adult life: Does insulin-like growth factor-I play a role