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In small doses, they can cause fever, tiredness and aches, but in large amounts, they can trigger life-threatening conditions like septic shock

Young children and infants are particularly susceptible to even low amounts of lead, and there is a significant reduction of cognitive function that has been reported by Rubin and Strayer (2008)

While useful as a simplified framework that characterizes microglia as either pro-inflammatory (M1) or protective/repair-oriented (M2), the classical M1/M2 dichotomy does not fully capture the diverse and dynamic activation states of microglia, which often exist along a phenotypic continuum between pro-inflammatory and protective functions (Tastan and Heneka, 2024

Kumar et al., 2011), defects in basal ganglia formed (Sian et al., 1994), and the ubiquitinproteasome system functioned poorly (Martin and Teismann, 2009), but the electron transport chain complex was unaffected (Heales et al., 2011)

*Correspondence: Yang Liu, [email protected] Shan, [email protected] Xia, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

The SCOPE study was conducted to determine the safety, feasibility and cost-effectiveness of a revised case management package for patients with P