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Bucillamine was shown to be safe in humans but not tested yet for the reduction of oxidative stress in the respiratory system of patients [81]

Taken together, these observations underscore how astrocytic metabolic and transporter dysfunctions underlie synaptic dysregulation and BBB disturbances in neurodegenerative diseases

The functional expression in Xenopus laevis oocytes microinjected with the DIC cRNA from rat liver did not result in significant GSH transport activity (Coll et al., 2003)

As original therapy in all conditions, in which rapid reorganization of blood circulation is mandatory

However, challenges such as the long-term survival and integration of transplanted cells within the hostile ALS microenvironment remain significant hurdles in preclinical models (60, 61)