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Importantly, in our comparative analyses, phenformin strongly outcompeted metformin in terms of its antiviral activity which was ~300 fold higher against SARS-CoV-2 (IC 50 of ~1.5 M for phenformin vs ~450 M for metformin)

[DOI] [PMC free article] [PubMed] [Google Scholar] 96.Dance D.A.B., Wuthiekanun V., Chaowagul W., White N.J

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Clinical Implications Adjunct Therapy : The study highlights GSH as a promising adjunct to standard anti-diabetic therapy, particularly in managing oxidative stress, which is a critical but often overlooked component of diabetes care