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The paper explores the science at the intersection of metabolic hormones and precision nutrition and multi-target therapies, like tirzepatide and retatrutide.

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However, recent work suggests that lipolysis may not be linear, as many of the protein players involved in adipocyte lipolysis are multifunctional enzymes able to catalyze reactions in both directions (20-22), resulting in the re-esterification and recycling of FAs (23), thereby challenging the current model