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There is a classification issue around that

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C., Blanco-Vaca F., Soria J

However, the relationship is not strictly linear there appears to be a plateau effect at higher doses, suggesting an optimal dosing range beyond which further increases provide diminishing returns

Unlike full-length growth hormone, which can cause edema (fluid retention), joint pain, carpal tunnel syndrome, glucose elevation, and increased IGF-1, AOD-9604 demonstrates none of these effects in clinical trials

Evidence revealed that endogenous and exogenous IGF-1 administration protects against the onset and progression of diabetic cardiomyopathy [278, 279]