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Finally, multi-omics approaches, integrating genomic, transcriptomic, proteomic, and metabolomic data, will refine precise toxicity prediction, allowing for a deeper mechanistic understanding of drug-induced liver injury

J Clin Med 6:86 Fang Q, Zheng B, Liu N, Liu J, Liu W, Huang X, Zeng X, Chen L, Li Z, Ouyang D (2021) Trimethylamine N-oxide exacerbates renal Inflammation and fibrosis in rats with diabetic kidney disease

A study from Mexico found that children with MS and T2DM, compared to healthy controls, exhibited an increase in facultative anaerobes like enteric and lactic acid bacteria, along with a decrease in obligate anaerobes such as Erysipelatoclostridium , Shaalia , and Actinomyces genera, which may cause loss of gut's hypoxic environment, enhanced gut microbial nitrogen metabolism, and increased generation of pathogen-associated molecular patterns

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