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Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russian Federation Boris Malyugin Samara Regional Ophthalmology Hospital, Samara, Russian Federation Andrey Zolotarev Irkutsk Branch of FBSI IRTC Eye Microsurgery, S.N

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Hierarchical clustering of commonly engaged proteins by the fold increase in target engagement in senescent versus non-senescent conditions (referred to as senescence selectivity) identified broadly highly-reactive proteins, clusters of proteins with specificity to certain chemotypes and others (such as GPX4) that were enriched in probes related to three different SCLAs (Fig

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