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More recently the Maastricht guidelines have suggested a search and treat approach which includes searching for and treating patients with a positive family history (first degree relative) of gastric cancer, aged at least 45, and presenting with alarm symptoms such as weight loss, dysphagia, overt gastrointestinal bleeding, abdominal mass or iron-deficiency anaemia

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K.KimJ.ZhuangL.et al (2020)

It was against this background that Jerne developed his model of 'natural selection theory'

Arts IS, Gennaris A, Collet J-F

The plantar fascia doesn't have that luxury, which is exactly why regenerative treatments work when cortisone doesn't