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In order to quantify the adiposity, at 2, 6 and 12 months, epididymal (EAT), mesenteric (MAT), and retroperitoneal (RPAT) fat pad were collected, weighed and used for the calculation of visceral adipose tissue index, obtained by the sum of the weight of all visceral adipose tissue fat pads (VAT), normalized by body weight of individual mice (Fig

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