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Its all of the little pebbles being added onto the scale, and it finally tips over into disease. Christina Applegates life turned upside down with an MS diagnosis at 49 Image credits: Matt Winkelmeyer/Getty Images Christina Applegate had spent decades as one of Hollywoods most recognizable actresses, rising to fame as Kelly Bundy on Married with Children before earning critical acclaim and Emmy nominations for her roles in Samantha Who

This approach involves stimulation of the cerebellar dentate nucleus, the origin of the DTC pathway, in order to enhance activity along this natural excitatory fiber tract and augment thalamocortical interactions across multiple prefrontal, frontal, and parietal cortical regions (Fig

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