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The injury models are clean and controlled - surgical cuts, not the messy reality of human tendinopathy or chronic overuse injuries

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The downstream serotonergic amplification isn't additive

Pruritus has been reported in 1.5% of patients receiving oral ketoconazole

In addition, as migraine prophylactic agents, 400 mg/day of riboflavin was comparable with 500 mg/day of sodium valproate and 100 mg/day of riboflavin was comparable with 80 mg/day of propranolol, with no statistical differences between groups in their prophylactic actions, with a more favorable side effect profile in the riboflavin groups (100)