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Using this model, it was found that a high-fat diet could aggravate the ferroptosis process and, together with ER stress, worsen the development of pancreatitis

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doi: 10.1007/s13311-014-0329-3

Age and oxidative stress Aging is the gradual decline in tissue and organ functionality over time 23

The central mechanism responsible for the accurate function of clock genes is based on a transcription/translation negative and positive feedback loop ( The positive branch of rhythmic genes consists of circadian locomotor output cycles kaput (CLOCK) and brain and muscle ARNT-like/basic helixloophelix ARNT-like 1 (BMAL1)