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These effects are correlated with a decreased astroglial reactivity and production of pro-inflammatory proteins, since ACEA did not impair A aggregation ( Similarly, CBD and THC have demonstrated neuroprotection in chronically treated APP/PS1 mice showing improvements in memory tasks and a decrease in soluble A42 levels, astrogliosis, and several neuroinflammation markers (Cheng D

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Additionally, these reactive species induce DNA oxidation, leading to mitochondrial and nuclear DNA mutations, further impairing ATP production and exacerbating ETC dysfunction

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Ghafouri-Khosrowshahi A, et al

(2002): Muscle Long-Chain Acyl CoA Esters and Insulin Resistance