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4.2.2 Gastrointestinal and hypertensive side effects of curcumin at high doses Although curcumin is best known for its anti-inflammatory and antioxidant properties, at high concentrations it can influence COX enzymes in a way that may lead to gastrointestinal or vascular side effects

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Oral supplementation may be appropriate for dietary deficiency in the absence of malabsorption

Addressing the Concerns Directly On tumor promotion: The angiogenesis mechanism has generated theoretical concern about potential tumor growth promotion