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Type 2 diabetes across generations: From pathophysiology to prevention and management

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Of these, CAT that uses iron as its electron acceptor, and PRX that uses sulfur-based cysteine 32 , both represent some of the most evolutionary ancient antioxidant enzymes targeting H 2 O 2

Timosaponin AIII (Tim-AIII), A steroid saponin, can bind to the heat shock protein 90 (HSP90), which further promotes the ubiquitination of GPX4 and thereby degrades GPX4 [279]

These findings revealed the important role that OAA plays in ensuring a balanced ROS level in CSCs

this includes the 16-amino-acid mitochondrial open reading frame of the 12 S rRNA type-c (MOTS-c), the 24-amino-acid humanin (HN), and the small-humanin-like peptides 16 (SHLP 16), which are between 20 and 38 amino acids [115,116,117,118]