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Copper is a co-factor for lysyl oxidase, the enzyme that cross-links newly synthesised collagen and elastin fibres into load-bearing structures

Current perspective on the regulation of FOXO4 and its role in disease progression

(1975) Lead-induced inclusion bodies: Results of EDTA treatment

Several factors can impair B12 absorption: Reduced stomach acid production (achlorhydria or hypochlorhydria), common in older adults and those taking proton pump inhibitors or H2-receptor antagonists long-term, impairs the release of B12 from food proteins Pernicious anaemia , an autoimmune condition destroying parietal cells and reducing intrinsic factor production, completely blocks the primary absorption pathway Gastrointestinal disorders including Crohn's disease, coeliac disease, or surgical removal of stomach or ileum sections directly damage absorption sites Metformin , commonly prescribed for type 2 diabetes, may reduce B12 absorption through unclear mechanisms