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Diagnosis generally involves blood tests to measure B12 levels

When that happens, it becomes significantly more difficult for cells to burn fat

Excessive nitric oxide levels may react with superoxide to produce peroxynitrite

A recurring theme across these studies is that mitochondrial dysfunction parallels NAD + metabolism alterations, contributing to the detrimental phenotypes in different tissues or at the organism level

Indication: Specifically for vitamin B12 deficiency due to supplemental insufficiency, certain anemias, gastrointestinal malabsorption, and neurological conditions associated with low B12 levels

Because of lack of renal clearance, serum values rose to more than a hundredfold from 422 pmol/L on average to 54 000 pmol/L, with 67 000 pmol/L as highest value, without side-effects