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Additionally, vitamin E supplementation is not entirely safe as higher doses have been associated with specific side effects, including hemorrhagic stroke (Sesso et al., 2008) and increased risk of prostatic cancer (Klein et al., 2011) (Table 1)

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Autophagy inhibition and ferroptosis activation during atherosclerosis: Hypoxia-inducible factor 1 inhibitor PX-478 alleviates atherosclerosis by inducing autophagy and suppressing ferroptosis in macrophages

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[DOI] [PMC free article] [PubMed] [Google Scholar] 41.Shen L, Kapsogeorgou EK, Yu M, et al

The study design was an open-label, randomized two-phase crossover study