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Increment in collagen content could also be clearly observed

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Statements Author contributions AR: Data curation, Formal analysis, Investigation, Methodology, Validation, Writing original draft

Arginine metabolic regulators such as spermidine have been shown to suppress M1 macrophage-associated cytokines while inducing M2 macrophage-related markers, significantly alleviating EAE symptoms, whereas Arg1 inhibitors can reverse these effects ( In other autoimmune diseases, amino acid metabolic reprogramming likewise participates in the formation of the inflammatory microenvironment by regulating macrophage polarization

Exericse intolerance and mitochondrial dysfunction in patients with Chronic Obstructive Pulmonary Disease

Lifespan assay Lifespan assays were performed as previously described 6,16