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Finally, we propose and highlight several important yet unanswered problems and some future research directions in this field

Gasteiger charges were added to the ligand, and maximum 6 number of active torsion are given to the lead compound using Auto Dock Tool ( Kollaman charges and solvation term were added to the protein structure using Auto Dock Tool

Other Targets in Melanogenesis Pathway Besides tyrosinase and melanogenic enzymes, other targets in the melanogenesis pathway have been the subject of research for anti-melanogenic active ingredients (Fig

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Those that can still be prescribed are listed below, specifically tirzepatide, semaglutide, sermorelin, TB-500, BPC-157, GHK-Cu, Thymosin-Alpha, Semax, Selank, HGH, and several others