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To explore the functional role of FOXO4 in senescence, its expression was silenced using siRNA in TM3 Leydig cells prior to H2O2-induced senescence

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Pharmacokinetics and pharmacodynamics of GS-9350: a novel pharmacokinetic enhancer without anti-HIV activity

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[45] reported an epigenetic regulation system based on exosomal CRISPR intervention (RVG-CRISPRi-Exo), which consisted of exosome membranes encapsulating sgRNA targeting specific regions of the CpG island (CGI) in the murine SNCA gene, the dCas9-DNMT3A fusion protein, and RVG-Lamp2b, for PD treatment (Fig

[DOI] [PMC free article] [PubMed] [Google Scholar] 119.Brakedal B., Dlle C., Riemer F., Ma Y.L., Nido G.S., Skeie G.O., et al