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Advanced chronic kidney disease (CKD) or acute kidney injury (AKI) resulting in a significant buildup of waste products in the body may cause diarrhea as well as vomiting, increased thirst, reduced appetite, lethargy, and bad breath

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Patients should be counseled about moderate alcohol consumption and the importance of monitoring for signs of hypoglycemia when consuming alcohol while on tirzepatide therapy

After that, take a 4-week break before starting again