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Quality control Research-use peptides are not held to pharmaceutical-grade manufacturing standards

A high level of acute oxidative stress causes the death of GPx1 knockout mice

WOS:000356735900011

In the case of proteins associated with glucose metabolism, loss of activity following HNE oxidative modification would lead to loss of ATP production

Therapeutically, the mTORC1 inhibitor rapamycin has been shown to reduce IL-17 secretion, restore Treg function, decrease autoantibody titers, and ameliorate nephritis [69]

doi: 10.1038/s41575-019-0247-2 2 van der SluisFJCouwenbergAMde BockGHIntvenMPWReerinkOvan LeeuwenBLet al