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Samuel, V

Curcumin has been found to induce ferroptosis in cancer cells while acting as an inhibitor of ferroptosis in tissue injuries

Further recent studies demonstrate that mtDNA not only acts as a ligand for cGAS to activate the STING pathway, but also exacerbates IFN-I-driven autoimmune inflammation through two additional mechanisms: metabolic-posttranslational modification regulation (e.g., lactylation modification enhances cGAS stability) and the formation of a positive feedback loop with cell death pathways (Zhang J

Gaskell EA, Smith JE, Pinney JW, Westhead DR, McConkey GA (2009)

Iimuro Y, Bradford BU, Yamashina S, Rusyn I, Nakagami M, Enomoto N et al

These findings illustrate that ILC2s are essential for initiating the early IL-5-dependent local and systemic eosinophil response after L